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Comparison of host genetic factors influencing pig response to infection with two North American isolates of porcine reproductive and respiratory syndrome virus

机译：影响猪对北美两株猪繁殖与呼吸综合征病毒分离株感染反应的宿主遗传因素的比较

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Background Porcine reproductive and respiratory syndrome (PRRS) is one of the most important swine diseases in the world and genetic selection of pigs for increased resistance to PRRS is an attractive method to improve the health status of the swine herd. This study compared phenotypic and genetic responses to infection with one of two genetically distinct type 2 PRRS virus (PRRSV) isolates: NVSL-97-7895 (NVSL) and KS-2006-72109 (KS06), and evaluated whether the single nucleotide polymorphism (SNP) WUR10000125 (WUR) on chromosome 4 that was associated with viral load and weight gain under infection with NVSL also has an effect on response to infection across North American PRRSV isolates. Wood’s lactation curve was fitted to repeated viremia measurements to derive five curve characteristics that were evaluated.Results Infection with NVSL was characterized by reaching a 14 ± 2 % higher peak viremia (PV) 2.5 ± 0.6 days earlier (time to peak; TP) than KS06, followed by 36 ± 1 % faster virus clearance, which occurred 3.9 ± 0.7 days sooner. Weight gain from 0 to 42 days post-infection (WG) tended to be higher under infection with KS06 than NVSL (3.7 ± 1.5 kg). Estimates of heritability were moderate for both PRRSV isolates for viral load from 0 to 21 days post-infection (VL) (NVSL: 0.31 ± 0.06; KS06: 0.51 ± 0.09) and WG (NVSL: 0.33 ± 0.06; KS06: 0.31 ± 0.09). Strong negative genetic correlations were observed between VL and WG for both NVSL (−0.74 ± 0.10) and KS06 (−0.52 ± 0.17) infected pigs. Pigs with genotype AB at the WUR SNP had a more desirable phenotype than AA pigs for all traits under infection with NVSL, but only for VL and PV with KS06; effects on other traits were smaller and not significantly different from zero (P \u3e 0.05). Genetic correlations of host response between isolates were strong for VL, WG and PV. Accounting for WUR genotype had little impact on these correlations, suggesting that response to PRRSV infection has a substantial polygenic component that is common between these two isolates.Conclusions These results suggest that the KS06 PRRSV isolate is less virulent than NVSL but that genetic selection for increased resistance to either of these genetically distinct isolates is expected to increase resistance to the other isolate.
机译：背景技术猪繁殖与呼吸综合征（PRRS）是世界上最重要的猪疾病之一，对猪进行遗传选择以提高其对PRRS的抵抗力是改善猪群健康状况的一种有吸引力的方法。这项研究比较了两种遗传学上不同的2型PRRS病毒（PRRSV）分离株之一（NVSL-97-7895（NVSL）和KS-2006-72109（KS06））对感染的表型和遗传反应，并评估了单核苷酸多态性（ SNP）4号染色体上的WUR10000125（WUR）与NVSL感染下的病毒载量和体重增加有关，也影响了北美PRRSV分离株对感染的反应。将伍德的泌乳曲线拟合到重复的病毒血症测量中，得出五个被评估的曲线特征。结果以NVSL感染为特征，其峰值病毒血症（PV）比2.5到0.6天（达到峰值的时间）提前了14±2％。 KS06，随后病毒清除速度提高了36±1％，发生时间提前了3.9±0.7天。感染KS06后0至42天的体重增加（WG）往往比NVSL（3.7±1.5 kg）高。感染后0至21天（VL）（NVSL：0.31±0.06; KS06：0.51±0.09）和WG（NVSL：0.33±0.06; KS06：0.31±0.09）的病毒载量的PRRSV分离株的遗传力估计均中等）。对于被NVSL（-0.74±0.10）和KS06（-0.52±0.17）感染的猪，在VL和WG之间观察到强烈的负遗传相关性。对于受NVSL感染的所有性状，具有WUR SNP基因AB型猪的表型比AA猪更理想，但对于KS06的VL和PV只表现出更好的表型。对其他性状的影响较小，且与零无显着差异（P <0.05）。 VL，WG和PV之间，分离株之间宿主反应的遗传相关性很强。考虑到WUR基因型对这些相关性影响很小，这表明对PRRSV感染的反应具有大量的多基因成分，这在这两个分离株之间很常见。结论这些结果表明，KS06 PRRSV分离株的毒性不如NVSL，但遗传选择对于预期对这些遗传上不同的分离株的抗性会增加对另一个分离株的抗性。

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